Voltage-gated Calcium Channel Antibody
(VGCCA)

Sample type:

• Serum.

Uses:

• Detect antibodies for P/Q type and N-type voltage-gated calcium channels.

• Aid in the evaluation of muscle weakness in the context neuromuscular junction disorder with or without cancer, or the diagnosis of paraneoplastic neurological syndromes.

Precautions:

• Centrifuge and aliquot serum to a transport tube within 1 hour of collection.

• Sterlize all equipment before use.

Interfering Factors: :

• VGCC antibodies may be found with paraneoplastic neuronal antibodies.

• VGCC antibodies was significantly higher in children with malaria and seizures.

Pre analytical errors:

1) Wrong Labeling of the Containers.

2) Errors in Specimen Preparation.

3) Inappropriate Laboratory Test Requisition.

4) Inadequate Volume.

Corrective action:

1) Make correct Labeling of the Containers.

2) No errors in Specimen Preparation.

3) Appropriate Laboratory Test Requisition.

4) Adequate Volume.

Post analytical errors:

1) Failure in reporting.

2) Erroneous validation of analytical data.

3) Improper data entry.

Corrective action:

1) Make agood report.

2) All analytical data should be available.

3) Proper data entry.

Reference range:

• Negative: 0.0:24.5 pmol/L.

• Interminate: 24.6:45.6 pmol/L.

• Positive: 45.7 pmol/L or greater.