Cryoglobulin

Sample Type

Serum

Uses

1. Evaluating cryoglobulins in patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases.

2. Evaluating cryoglobulins in patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure

Precautions

1. Specimen must be drawn in a prewarmed tube and kept at 37°C while clotting.

2. Separate serum from cells immediately after clot formation (keep at 37°C while clotting), and transfer serum into a clean transport tube.

3. Patient should be fasting.

Interfering factors

1. Infections such as Lyme disease, infectious mononucleosis (mono), hepatitis C and HIV/AIDS.

2. Kidney disease.

3. Autoimmune diseases such as systemic lupus erythematosus, rheumatoid and arthritis.

4. Diseases characterized by an increase in lymphocytes such as multiple myeloma, lymphoma and lymphoid leukemia.

Pre Analytical Errors

1. Write another patient’s name.

2. Improper labelling;

3. Gross hemolysis.

Corrective action

1) Make sure you write the correct name in the report.

2) Rejected sample hemolyzed and haven’t label.

Post analytical errors

1. Delayed reported.

2. Incorrect calculation.

Corrective actions

Review the report before submitting it, but if the report is delivered to the patient must inform him of the right.